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Microdosing: A Glimmer of Hope for Anxiety and Depression

microdosing for relief from anxiety and depression

In recent years, there's been a surge in interest around the concept of microdosing—taking sub-perceptual amounts of psychedelic substances—as a potential alternative to traditional treatments for anxiety and depression. This article delves into the emerging science behind microdosing and its potential benefits for those grappling with these common mental health challenges.

What is Microdosing?

Microdosing involves taking a fraction of the dose that would produce full-blown hallucinogenic effects—typically about 1/10th to 1/20th of a recreational dose. Common substances used for microdosing include LSD (lysergic acid diethylamide) and psilocybin (found in certain mushrooms).

The idea is not to experience a "trip," but rather to attain subtle physiological and psychological effects that can influence mood, cognition, and well-being.

The Science Behind It

While large-scale, rigorous clinical trials on microdosing are still in their infancy, preliminary studies and anecdotal reports suggest promising results.

  1. Neuroplasticity: Psychedelics are believed to promote neuroplasticity—the brain's ability to form and reorganize synaptic connections. This could potentially aid in breaking the cycle of negative thought patterns often seen in depression.

  2. Serotonin System: Just like many conventional antidepressants, psychedelics influence the serotonin system in the brain. Serotonin is a neurotransmitter that plays a pivotal role in mood regulation.

  3. Default Mode Network (DMN): Research indicates that psychedelics can reduce the activity of the DMN. An overactive DMN is linked to rumination and self-critical thoughts, common in both anxiety and depression.

Microdosing for Anxiety and Depression

Many individuals who have tried microdosing report a range of positive outcomes, including:

  • Enhanced mood and increased emotional stability.

  • Boosted creativity and problem-solving skills.

  • Reduced anxiety and improved social interactions.

  • A heightened sense of presence and mindfulness.

However, it's crucial to approach these anecdotes with a degree of skepticism, as placebo effects and confirmation bias can play significant roles in self-reported outcomes.

The Road Ahead

Several institutions are now taking a closer look at the potential therapeutic benefits of psychedelics, including microdosing. Initial results are promising. For instance, a study from the Beckley Foundation found that microdosing LSD can have a positive impact on mood and cognition.

However, it's essential to highlight that microdosing is not a one-size-fits-all remedy. The effects can vary based on individual factors like body chemistry, the specific substance used, and dosage.

Potential Risks

As with any substance, there are potential risks involved:

  • Legal Implications: Many psychedelic substances are illegal in numerous countries, even in microdoses.

  • Unpredictable Effects: Everyone's body reacts differently, and there's always a chance of experiencing unwanted side effects.

  • Interactions with Other Medications: Psychedelics might interact with other medications or underlying health conditions.


Microdosing presents an intriguing potential alternative or adjunct to conventional treatments for anxiety and depression. As more research emerges, we'll gain a clearer understanding of its efficacy and safety.

However, until then, it's essential to approach the topic with an open mind, rooted in scientific inquiry, and always consult with a healthcare professional before making any decisions regarding treatment.

If you are looking for a program that can help you navigate the nuances of an effective microdosing protocol, sign up for our latest Beyond Microdosing Course. This is a self -paced course that will help you make the most of your microdosing practice and optimize your self-care.

Disclaimer: This article is informational and does not constitute medical advice. Always consult with a medical professional before making decisions regarding treatments or medications.

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