top of page

The Emerging Role of Psychedelics and Polyvagal Theory in Trauma Therapy: Insights and Implications

LSD and trauma

Polyvagal Theory, developed by Dr. Stephen Porges, offers a new understanding of how the autonomic nervous system responds to stress and trauma. It's become influential in the fields of psychology, trauma therapy, and various forms of therapy aimed at emotional regulation and social behavior.

Understanding Polyvagal Theory:

The theory is named after the vagus nerve, which is a major part of the parasympathetic nervous system. The vagus nerve is responsible for regulating several bodily functions, including heart rate, breathing, and digestion. Polyvagal Theory proposes that the autonomic nervous system, of which the vagus nerve is a part, has three distinct parts:

  1. The Ventral Vagal Complex: Associated with the parasympathetic nervous system, it promotes a state of calm and safety. It's active when we feel relaxed and socially engaged. This is the newest system in our evolutionary history and supports social communication and self-soothing behaviors.

  2. The Sympathetic Nervous System: Activated in response to perceived threats, it prepares the body for a "fight or flight" reaction. When this system is activated, we may feel anxious, stressed, or angry.

  3. The Dorsal Vagal Complex: The oldest part of the autonomic nervous system, it can trigger a "freeze" or "shutdown" response when faced with overwhelming threat or trauma. This response is a primitive way of protecting ourselves by becoming immobilized or playing dead.

Polyvagal Theory and Trauma Healing:

In the context of trauma, Polyvagal Theory provides insight into how trauma affects the body and the nervous system. Understanding these physiological responses can be crucial in trauma therapy. Here’s how it works to heal trauma:

  1. Recognizing Physiological States: The theory helps individuals and therapists recognize which state of the nervous system is activated. This awareness is the first step in learning how to shift out of maladaptive responses (like fight, flight, freeze) to more adaptive states (like social engagement and calm).

  2. Building Safety and Trust: Trauma can make the world feel unsafe and unpredictable. Therapy based on Polyvagal Theory involves creating a sense of safety and trust, which can help activate the ventral vagal complex. This may involve creating a safe physical space, as well as a trustworthy and predictable therapeutic relationship.

  3. Practicing Self-Regulation: Teaching and practicing self-regulation techniques, such as deep breathing, meditation, or mindfulness, can help activate the parasympathetic nervous system and promote feelings of calm and safety.

  4. Social Engagement: Engaging in positive social interactions is also a key aspect. Positive social experiences can help rewire the nervous system towards safety and trust, essential in healing from trauma.

  5. Body-Oriented Therapies: Since trauma responses are deeply embedded in the body’s nervous system, body-oriented therapies like yoga, dance, or somatic experiencing can be effective in releasing and processing trapped trauma.

  6. Titration and Pendulation: Gradually exposing a person to traumatic memories (titration) and then bringing them back to a safe, present state (pendulation) can help in processing trauma without overwhelming the nervous system.

Polyvagal Theory offers a framework for understanding the deep connection between psychological experiences and physiological states, particularly in the context of trauma. By leveraging this understanding, therapists can guide individuals in navigating their trauma responses more effectively, paving the way for healing and resilience.

The intersection of psychedelics and Polyvagal Theory is an emerging area of interest in the field of psychopharmacology and psychology. While there is not a direct one-to-one relationship between the effects of psychedelics and Polyvagal Theory, there are several ways in which the use of psychedelics might intersect with, complement, or mimic aspects of the theory, particularly in the context of trauma healing and emotional regulation.

Psychedelics and Their Effects on the Brain:

Psychedelics, including substances like LSD, psilocybin, and MDMA, are known to have profound effects on the brain's serotonin system. They often induce states of altered consciousness, which can include changes in perception, emotion, and cognition. These effects can potentially influence the way the brain processes trauma and stress.

Psychedelics and Polyvagal Theory:

  1. Enhancing Neural Plasticity: Psychedelics are known to promote neural plasticity – the brain's ability to change and adapt. This increased neural plasticity might facilitate the kind of neurophysiological changes that Polyvagal Theory describes as beneficial for overcoming trauma, such as shifting from a state of defensive "shutdown" (dorsal vagal response) to states of safety and social engagement.

  2. Emotional Processing and Integration: Many psychedelic-assisted therapies focus on helping individuals process and integrate difficult emotional experiences. This aspect of therapy can align with Polyvagal Theory's emphasis on moving out of maladaptive emotional responses and fostering states of safety and connection.

  3. Altering Perception of Safety and Threat: Psychedelics can alter a person's perception and cognitive processing, which might influence how they perceive safety and threat in their environment. This can be particularly relevant in the context of trauma, where the nervous system might be stuck in a state of heightened threat perception.

  4. Facilitating Social Connectivity: Certain psychedelics, particularly MDMA, have been shown to enhance feelings of empathy and social connectedness. This effect could potentially help engage the ventral vagal system, promoting feelings of safety and social engagement, which are crucial in trauma recovery.

  5. Mindfulness and Present-State Awareness: Psychedelics often induce a state of heightened present-state awareness, similar to mindfulness. This state can help individuals become more aware of their bodily sensations and emotional states, which is an essential aspect of Polyvagal Theory in managing trauma responses.

Considerations and Research:

  • Research is Ongoing: The research on how psychedelics might intersect with Polyvagal Theory is still in its early stages. Most of the connections are theoretical and based on the observed effects of psychedelics and the principles of Polyvagal Theory.

  • Individual Differences: The response to psychedelics can be highly individual, influenced by factors like set (mindset/expectations) and setting (environment). This variability is also a key consideration in Polyvagal Theory, which acknowledges individual differences in nervous system responses to stress and trauma.

  • Clinical Settings: Psychedelic-assisted therapy is typically conducted in controlled, therapeutic settings, which are designed to ensure safety and support the therapeutic process. This controlled environment can help in creating the sense of safety that is central to Polyvagal Theory.

While there is no direct causal link established between psychedelics and Polyvagal Theory, there are several areas where the effects of psychedelics might complement or mimic the principles of Polyvagal Theory, particularly in the context of emotional processing and trauma therapy. Future research is needed to explore these intersections further and to understand the potential therapeutic applications.

Exploring the Psychedelic Renaissance: In recent years, there's been a resurgence in research on psychedelics, including LSD, for their potential therapeutic benefits. This "psychedelic renaissance" is exploring how these substances can aid in treating various mental health disorders, including those rooted in trauma.

LSD's Mechanism of Action: LSD is known for its profound impact on consciousness, perception, and emotions. By interacting with serotonin receptors in the brain, LSD creates a unique state of heightened neural plasticity and connectivity. This state could potentially allow for the reprocessing and integration of traumatic memories, which is a cornerstone of trauma therapy.

The Role of Set and Setting: An important aspect of psychedelic therapy, including with LSD, is the concept of "set and setting." This refers to the individual's mindset and the physical and social environment in which the experience takes place. A supportive, controlled and, if possible, a natural and beautiful setting is crucial for positive therapeutic outcomes.

LSD and Neuroplasticity: Studies suggest that LSD and other psychedelics promote neuroplasticity — the brain's ability to form new connections and pathways. This could be crucial in helping individuals reframe and move past traumatic experiences (Ly et al., 2018).

The Future of Research: Ongoing research is required to fully understand and validate the use of LSD in trauma therapy. This includes clinical trials, long-term follow-ups, and comprehensive evaluations of risks and benefits.

The exploration of LSD in the context of trauma therapy is part of a broader movement towards understanding and leveraging the potential of psychedelic substances in mental health treatment.

Understanding LSD's Potential in Trauma Therapy: Insights from Polyvagal Theory and Emerging Research

LSD: Lysergic Acid Diethylamide (LSD) is a psychedelic known for its significant effects on consciousness, perception, and emotions. Its interaction with serotonin receptors in the brain leads to a heightened state of neural connectivity and emotional openness. This rekindled interest in its therapeutic potential, especially for mental health conditions such as depression, anxiety, and PTSD.

The Intersection with Polyvagal Theory: LSD's potential to influence neural plasticity and emotional processing could intersect with the principles of Polyvagal Theory. This intersection lies in the ability of psychedelics to potentially facilitate the 'vagal brake,' aiding individuals in recovering from stress or traumatic experiences by promoting states of calm and safety.

Clinical Research and Case Studies: While recent specific case studies directly linking LSD to trauma recovery are just beginning to emerge again, there is great promise in the potential of psychedelic-assisted therapy is being explored:

  1. Psychedelic-Assisted Psychotherapy: Research has shown that psychedelics can enhance psychotherapeutic processes, potentially aiding in the reprocessing of traumatic memories (Gasser et al., 2014; MAPS, ongoing research on MDMA).

  2. Neuroplasticity and LSD: Studies indicate that LSD increases neural plasticity, which might facilitate nervous system reorganization in a way that aligns with Polyvagal Theory (Ly et al., 2018).

  3. Emotional Regulation and Psychedelics: LSD's effect on emotional regulation is a key aspect of trauma response and a central component of Polyvagal Theory (Preller et al., 2016).

Clinical Implications and Future Research: The exploration of LSD in trauma therapy, potentially aligned with Polyvagal Theory, could revolutionize trauma treatment. However, this field requires more targeted studies to understand and harness this potential fully. The future of LSD in trauma therapy is part of a broader movement towards leveraging psychedelics in mental health treatment.


  1. Gasser, P., Holstein, D., Michel, Y., Doblin, R., Yazar-Klosinski, B., Passie, T., & Brenneisen, R. (2014). Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases. The Journal of Nervous and Mental Disease, 202(7), 513.

  2. Ly, C., Greb, A. C., Cameron, L. P., Wong, J. M., Barragan, E. V., Wilson, P. C., ... & Olson, D. E. (2018). Psychedelics promote structural and functional neural plasticity. Cell reports, 23(11), 3170-3182.

  3. Preller, K. H., Herdener, M., Pokorny, T., Planzer, A., Kraehenmann, R., Stämpfli, P., ... & Vollenweider, F. X. (2016). The fabric of meaning and subjective effects in LSD-induced states depend on serotonin 2A receptor activation. Current Biology, 26(3), 451-457.

  4. Mithoefer, M. C., Wagner, M. T., Mithoefer, A. T., Jerome, L., Martin, S. F., Yazar-Klosinski, B., ... & Doblin, R. (2011). The safety and efficacy of ±3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study. Journal of Psychopharmacology, 25(4), 439-452.

  5. Griffiths, R. R., Johnson, M. W., Carducci, M. A., Umbricht, A., Richards, W. A., Richards, B. D., ... & Klinedinst, M. A. (2016). Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of Psychopharmacology, 30(12), 1181-1197.

28 views0 comments


bottom of page